Three plaque-composition factors predict ischemia in intermediate-sized coronary plaques

From Theheart.org JUNE 10, 2010 | Reed Miller

Salt Lake City, UT – Coronary computed-tomography angiography (CCTA) can identify which intermediate-sized plaques are most likely to cause ischemia without requiring follow-up perfusion imaging, a new study shows [1].

This week here at the Society of Nuclear Medicine 2010 Annual MeetingDr Haim Shmilovich (Cedars-Sinai Medical Center, Los Angeles, CA) presented results from a retrospective analysis of 34 coronary disease patients whose stenotic plaque obstructed between 70% and 89% of the lumen. All of the patients under

went CCTA and myocardial perfusion imaging within six months.

The results suggest that severely stenotic plaques containing certain adverse plaque characteristics that appear on CCTA, especially a lipid core, are more likely to produce significant ischemia than plaques without those characteristics.

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